City of Hope, one of the largest cancer research and treatment organizations in the United States, presented new research on beta cells, insulin secretion, and islet transplantation at the annual American Diabetes Association (ADA) Conference. The research aims to improve understanding of type 1 and type 2 diabetes and enhance treatment options.
The studies conducted by City of Hope scientists focused on various aspects related to diabetes. One study highlighted a better understanding of how beta cells respond to stress, which is a key factor in their dysfunction. Another study explored potential therapeutic targets for enhancing insulin secretion, while another looked at progress in improving single islet transplantation outcomes.
In terms of beta cell response to stress, researchers found that cellular stress impairs the mechanisms that allow beta cells to grow and become functional. Chronic exposure to stress leads to senescence and dysfunction in these cells. The findings provide insights into the fundamental mechanisms involved in beta cell damage and potential ways to protect and reverse it.
Another study identified a protein called Myc as a master regulator of insulin secretion. By controlling the function of mitochondria