Infinity Pharmaceuticals Provides Additional Information on MARIO-8 Study Evaluating Eganelisib in Combination with Pembrolizumab (KEYTRUDA®)

to patients with squamous cell cancer of the head and neck. He also expressed confidence in the potential of eganelisib in combination with pembrolizumab to improve outcomes for these patients.

The MARIO-8 study is part of Infinity's broader development program for eganelisib, which includes ongoing studies in other indications such as triple-negative breast cancer and non-small cell lung cancer. The company is committed to exploring the full potential of eganelisib across a range of tumor types and treatment settings.

Eganelisib is a first-in-class, oral immuno-oncology drug that selectively inhibits phosphoinositide-3 kinase-gamma (PI3K-gamma). By targeting this specific pathway, eganelisib has the potential to enhance anti-tumor immune responses and overcome resistance to checkpoint inhibitors like pembrolizumab.

Infinity Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company focused on developing novel therapies for the treatment of cancer. With a strong pipeline and strategic partnerships, Infinity is well-positioned to make significant contributions to the field of oncology.