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Direct Biologics Announces Publication of Significant Survival Benefit with ExoF

Direct Biologics LLC, a biotechnology company in the late stages of development, has recently published groundbreaking findings from their Phase 2 clinical trial in the prestigious Journal CHEST. The trial focused on evaluating the effectiveness of ExoFlo™, a regenerative medicine platform that utilizes extracellular vesicles (EVs) derived from bone marrow-derived mesenchymal stem cells (BM-MSCs..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 7. 13.
  • textsms

Simcha Therapeutics Announces First Patient Dosed in Phase 1/2 Study Evaluating ST-067 in Combination with KEYTRUDA® (Pembrolizumab) in Patients with Various Solid Tumors

Simcha Therapeutics, a clinical-stage immunobiology company, has announced that the first patient has been dosed in a Phase 1/2 clinical trial of ST-067 in combination with Merck's anti-PD-1 therapy, KEYTRUDA®, for patients with advanced solid tumors. The study aims to determine the maximum tolerated dose and preliminary activity of the combination treatment. Simcha Therapeutics has observed pro..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 7. 7.
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Liberate Medical Secures $6.2M in Series B Financing

Liberate Medical Secures $6.2M in Series B Financing Series B Co-Led by a Large Strategic Investor and Scientific Health Development to Support the Pivotal Clinical Trial of the VentFree® Respiratory Muscle Stimulator CRESTWOOD, Ky.--(BUSINESS WIRE)-- Liberate Medical, an emerging leader in the development of novel non-invasive neurostimulation devices focused on transforming respiratory care, a..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 7. 6.
  • textsms

InnoCare Announces First Psoriasis Patient Dosed in Clinical Trial of TYK2 Allosteric Inhibitor ICP-488 in China

InnoCare Pharma (HKEX: 09969; SSE: 688428) has announced that the first psoriasis patient has been dosed in a clinical trial of their TYK2 allosteric inhibitor ICP-488 in China. The phase I clinical trial has already completed single ascending doses (SAD) and multiple ascending doses (MAD) of ICP-488, showing a well-tolerated safety profile. The ongoing study aims to evaluate the safety and effi..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 7. 6.
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Positive Aggregate Safety Data From Vafidemstat’s Ongoing Phase IIb PORTICO Trial in Borderline Personality Disorder

Positive Aggregate Safety Data From Vafidemstat’s Ongoing Phase IIb PORTICO Trial in Borderline Personality Disorder &nbsp Recommendation from the independent Data Monitoring Committee (DMC) to continue the PORTICO trial based on positive safety data from the initial 167 randomized patients. PORTICO plans to recruit 188 patients. &nbsp MADRID, Spain and BOSTON, July 05, 2023 (GLOBE NEWSWIRE) -- ..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 7. 6.
  • textsms

Viracta Therapeutics' NAVAL-1 Trial Achieves Efficacy Threshold for Expansion in Relapsed or Refractory EBV-positive Peripheral T-Cell Lymphoma

Viracta Therapeutics, Inc. (Nasdaq: VIRX) has announced that its pivotal NAVAL-1 clinical trial has achieved the efficacy threshold for expansion in relapsed or refractory EBV-positive peripheral T-cell lymphoma (R/R EBV+ PTCL). This milestone allows the trial to move into Stage 2, indicating a strong signal of efficacy in treating this type of cancer. The NAVAL-1 trial is a global, multicenter ..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 29.
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Freya Biosciences Announces Positive Topline Clinical Trial Results for FB101 in Women with Asymptomatic Vaginal Dysbiosis

Freya Biosciences, a trans-Atlantic biotech company specializing in women's health, has announced positive topline results from its first Phase 1 clinical study of FB101. This investigational vaginal microbial immunotherapeutic has shown promising results in treating asymptomatic vaginal dysbiosis. The study was conducted in Europe and evaluated the change in vaginal microbiome after three conse..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 28.
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TransCode Therapeutics Announces Publication of New Data Supporting the Use of TTX-MC138 for the Treatment of Metastatic Breast Cancer

TransCode Therapeutics has announced new data supporting the use of TTX-MC138 for the treatment of metastatic breast cancer. The RNA oncology company's lead therapeutic candidate, TTX-MC138, is designed to inhibit microRNA-10b, described as the master regulator of cancer progression in a number of advanced solid tumors including breast cancer. In a preclinical model of pancreatic adenocarcinoma,..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 26.
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Seelos Therapeutics Closes Enrollment of Study for Intranasal Ketamine Treatment for Acute Suicidal Ideation and Behavior in Major Depressive Disorder Patients

Seelos Therapeutics has completed enrollment in its registration-directed study of SLS-002, an intranasal racemic ketamine for treating acute suicidal ideation and behavior (ASIB) in adults with major depressive disorder (MDD). The two-part clinical trial includes an open-label cohort followed by a randomized, double-blind, placebo-controlled study. Seelos aims to address the unmet need for ther..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 23.
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TransCode Therapeutics Announces Publication of New Data Supporting the Use of TTX-MC138 for the Treatment of Metastatic Breast Cancer

TransCode Therapeutics has published new data supporting the use of TTX-MC138 for the treatment of metastatic breast cancer. The lead therapeutic candidate, designed to inhibit microRNA-10b, has been shown to impair the capacity of cancer stem cells to create new tumors and become metastatic in breast cancer cells. Inhibiting these cells could improve outcomes in patients with recurrent and resi..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 23.
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