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Simcha Therapeutics Announces First Patient Dosed in Phase 1/2 Study Evaluating ST-067 in Combination with KEYTRUDA® (Pembrolizumab) in Patients with Various Solid Tumors

Simcha Therapeutics, a clinical-stage immunobiology company, has announced that the first patient has been dosed in a Phase 1/2 clinical trial of ST-067 in combination with Merck's anti-PD-1 therapy, KEYTRUDA®, for patients with advanced solid tumors. The study aims to determine the maximum tolerated dose and preliminary activity of the combination treatment. Simcha Therapeutics has observed pro..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 7. 7.
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First Patient Dosed in Phase II STARBURST Study of TLX250-CDx Exploring Indication Expansion

Telix Pharmaceuticals has announced the dosing of the first patient in a Phase II study of TLX250-CDx, an imaging agent that targets carbonic anhydrase (CAIX) and is being investigated across a range of cancer indications. The STARBURST study will explore CAIX expression in patients with diverse solid tumours for potential diagnostic and therapeutic applications. Tumours expressing CAIX are typi..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 20.
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Kymera Therapeutics Announces Updated Clinical Data from the Phase 1 Trials of STAT3 Degrader KT-333 and IRAKIMiD Degrader KT-413

Kymera Therapeutics, a clinical-stage biopharmaceutical company, has released updated clinical data from the phase 1 trials of STAT3 Degrader KT-333 and IRAKIMiD Degrader KT-413. The new data shows that both programs continue to demonstrate substantial target knockdown in ongoing clinical trials with no dose limiting toxicities observed. Kymera is developing these drugs to target protein degrada..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 11.
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Elevation Oncology Announces Pricing of $50 Million Public Offering

Elevation Oncology, a company focused on developing selective cancer therapies for solid tumors with significant unmet medical needs, has announced the pricing of an underwritten public offering of common stock and pre-funded warrants to purchase shares of common stock. The combined offering price is $2.2500 per share of common stock and accompanying warrant and $2.2499 per pre-funded warrant an..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 10.
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Enochian BioSciences Announces that its Cancer Platform Remains on Track for Trials in Humans Following FDA Review

Enochian Biosciences' Cancer Platform on Track for Human Trials by 2024 Enochian Biosciences has announced that its innovative Cancer Platform is expected to undergo clinical trials in humans during the first half of 2024. The US Food and Drug Administration (FDA) recently confirmed this after reviewing Enochian's Pre-Investigational New Drug Application submission. The company’s technology uses..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 9.
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BioInvent Announces Additional Efficacy Data from Intravenous Part of Phase 1/2 Trial with BI-1206 in Solid Tumors

BioInvent announces additional efficacy data from Phase 1/2 trial with BI-1206 in solid tumors, including one patient with long-lasting stable disease and another experiencing a partial response. The study is testing the novel anti-FcyRIIB antibody in combination with pembrolizumab for patients who have previously progressed on PD-1/PD-L1 immune checkpoint inhibitors. The results suggest that BI..

  • format_list_bulleted Pharmacology/BS
  • · 2023. 6. 8.
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